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Creators/Authors contains: "Foss, Jr., Frank_W"

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  1. ; ; ; ; ; ; (, ChemBioChem)
    Abstract The rational design of materials with cell‐selective membrane activity is an effective strategy for the development of targeted molecular imaging and therapy. Here we report a new class of cationic multidomain peptides (MDPs) that can undergo enzyme‐mediated molecular transformation followed by supramolecular assembly to form nanofibers in which cationic clusters are presented on a rigid β‐sheet backbone. This structural transformation, which is induced by cells overexpressing the specific enzymes, led to a shift in the membrane perturbation potential of the MDPs, and consequently enhanced cell uptake and drug delivery efficacy. We envision the directed self‐assembly based on modularly designed MDPs as a highly promising approach to generate dynamic supramolecular nanomaterials with emerging membrane activity for a range of disease targeted molecular imaging and therapy applications. 
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